"…For a long time we’ve seen Gram negatives develop resistance to
antibiotics, but we had other tricks up our sleeves. We had other
antibiotics that we could use.
Increasingly, though, what we’ve seen is that they’re developing
resistance even to the agents that we’ve been sort of holding back and
only using in the most serious infections. They were our last, best line
of defense, and we now see some of these Gram-negative organisms that
are resistant to even that last line of defense.
What that means is that we’ve had to actually reach back into the
archives, if you will. We’ve had to dust off the shelves [and revisit]
some older antibiotics that we haven’t used in many, many years. We
stopped using them because they were very toxic, and as new antibiotics
came about that weren’t so toxic, we of course stopped using these older
well great. When there's no defense against some diseases, that throws us way back to the Dark Ages where "doctors" ran around looking like this...